Ethiopia’s major public health problems include chronic food insecurity and malnutrition. A particular concern is the Vitamin A deficiency (VAD) affecting pregnant and breastfeeding women, and children under 5 years. To address this concerns integration of nutritious crop such as Orange fleshed sweetpotato (OFSP) into local farming and marketing system is needed. This brief reports on efforts that created an environment in which vulnerable populations could access key nutrients provided by OFSP and potato in an affordable and sustainable manner. It also documents a school-based model (school gardens and school feeding) proving to be an effective strategy for disseminating nutrition and agriculture knowledge to farmers and influencing behavioral change at household level.