This brief reports on project aimed towards breeding sweetpotato varieties with high level of virus resistance. Additionally, ensure the breeding methods are more efficient in producing improved populations with high expression of sweet potato virus disease (SPVD) resistance and quality characteristics desired by farmers and consumers. briefly selected SPVD resistant parents were included in two crossing blocks, one with 80 parents and a smaller one with 50 parents in Uganda. The two populations (in physically separated crossing blocks) had been previously differentiated on the basis of simple sequence repeat (SSR) markers. In conclusion, these crossing blocks generated populations for SPVD resistance and molecular marker development, and optimization of procedure to discriminate SPVD susceptible, tolerant and resistant varieties.