Kwame Nkrumah University of Science and Technology (KNUST) in collaboration with its partners is repositioning sweetpotato in Ghana’s food economy for health and wealth creation, making it an entrepreneurial hub in Africa. The capacities of participants of its annual Sweetpotato Training of Trainers (ToT) Course dubbed “Everything you need to know about sweetpotato” have been built for community impact and engagement. Four editions have been organized so far with participants from 16 different countries in Asia, America and Africa. Most of the participants have imparted the acquired skills and knowledge from the ToT course to farmers in their communities; a few have established sweetpotato businesses.