Resistance to weevils, Cylas puncticollis and C. brunneus, is very low in the available sweetpotato germplasm. Two cry genes are now accessible in Uganda for the improvement of resistance to weevils in sweetpotato through genetic transformation. The objective of the reported research is to develop an in vitro method of regenerating Ugandan sweetpotato for application of genetic transformation.  The results show that both cultivar and type of plant organ are significant factors affecting somatic embryogenesis. These findings pave the way for application of genetic transformation to improve resistance to weevils in Ugandan sweetpotato germplasm.