Fourteen cultivars/clones of sweetpotato were delivered to AGERI from International Potato Center (CIP) Nairobi in 2002 as cuttings. They were propagated in vitro for massive micro-propagation. Different media compositions and incubation conditions were examined to determine the optimal conditions for each cultivar. In vitro plants were acclimatized under an insect–proof greenhouse and used as mother plants for the cuttings to be evaluated at the AGERI experimental field as well as at Kafr El Zayat location. After harvesting, yield was evaluated on bases of weight and number of roots. Eight cultivars and lines have promising yield productivity under Egyptian conditions.