Sweetpotato (Ipomoea batatas) is one of the most important food crops in the world. In developing countries, it is a famine reserve crop and consumed by the poor rural populations for subsistence. However, it is attacked by a number of diseases, especially viruses. This article describes the sweetpotato chlorotic stunt virus (SPCSV) an important pathogen of SP. Additionally; it outlines the new gene transfer technology for combating resistance against SPCSV.