Weevil is a major threat to sweetpotato, which plays a vital role in food security and income generation for both the urban and rural poor in Sub-Saharan Africa. Weevils can devastate sweetpotato production, and even cause total crop loss. Weevil resistant varieties are the most sustainable solution to this problem. They could potentially increase food production by 25% for populations threatened by malnutrition in Sub-Saharan Africa. This brief covers a promising approach, Biotechnology, which offers the potential to develop resistant varieties that could be rapidly adopted and contribute to food security and income for African population threatened by malnutrition.