Malawi is experiencing challenges of climate change, declining soil fertility and population increase. These factors are negatively influencing livelihoods of poor households. Therefore, food diversification is a core agricultural policy needed to create opportunities for combating these challenges. The orange fleshed sweetpotato (OFSP) is a Vitamin A powerhouse that was initiated to raise household income and sweetpotato yields. The conceptual frame work outlined led to increment in numbers of OFSP beneficiaries with subsequent high yields. This presentation reports an overview of Sweetpotato for Profits and Health Initiative (SPHI) phase I project achievements and challenges.