In this article the Reaching Agents of Change (RAC) project focuses on three key goals. These include, 1) Mobilization of at least $18 million to orange-fleshed sweetpotato (OFSP) dissemination programs in five target countries (Tanzania, Mozambique, Nigeria, Ghana and Burkina Faso); 2) Substantial progress by a cadre of trained African advocates in ensuring that the use of OFSP is an integral part of strategies that address food insecurity and micronutrient malnutrition at regional and sub-regional levels in Sub-Saharan Africa (SSA) as well as in the five RAC target countries; and 3) Establishment of technical capacity for successful OFSP project implementation and continued awareness raising, resource mobilization, and change agent training efforts to continue once the project has ended. The Situation Analysis is a tool for the African advocates working on RAC’s second key goal. The orange-fleshed sweetpotato (OFSP) advocates will target regional and sub-regional organizations to ensure that OFSP is included in their food security, nutrition and micronutrient strategies. As such, this document identifies 16 regional/sub-regional organizations and 7 international organizations and initiatives that are potential partners for promoting OFSP. The entry for each organization includes: background information; the region or sub region the organization targets (except in the case of the international organizations and initiatives, which work globally); how the organization influences policy; the initiatives sponsored by the organization that are most closely related to RAC initiatives (biofortification, food-based approaches to combating vitamin A deficiency, distribution of plant materials to farmers etc.); and contact information for the organization, including relevant website addresses. The information is this Situation Analysis is not meant to be exhaustive and is therefore brief and targeted to the RAC project’s needs. It is hoped that this analysis will be useful to the OFSP Advocates in making initial contact with relevant regional and sub-regional organizations.