The 6th Annual Sweetpotato for Profit and Health Initiative SPHI) meeting took place from 29 September and 1 October 2015 in Kigali Rwanda. The theme of the 2015 meeting was ‘Together, 10 million by 2020’. This refers to the overall goal of the Sweetpotato for Profit and Health Initiative which is to reduce malnutrition and increase incomes among at least 10 million sub-Saharan African households through improved varieties of sweetpotato and their diversified use by 2020. The meeting was attended by 104 participants (scientists and experts, government representatives, academics and donors from the agriculture, nutrition and development communities) from across sub-Saharan Africa, Latin America and North America. They presented and discussed progress in sweetpotato science and delivery along the entire sweetpotato value chain, showcased innovations and impact case studies in agriculture, nutrition and health innovations and outlined the state of sweetpotato investment in sub-Saharan Africa. This is the full report of the proceedings.