A nutrient media for multiplying pre-basic sweetpotato vines under a sandponics system was optimized. The vine multiplication rate for pre-basic seed multiplication increased by 22% using sandponics. The cost of producing a 3-node cutting has been reduced by $0.027. Root yields were 7.1 t/ha higher using sandponics sourced planting material compared to material sourced from the conventional screen house production system.