The development of an economically feasible and sustainable vine multiplication models and vine distribution channels is critical for obtaining high sweetpotato yields. A study was done in Uganda and Tanzania in early 2018 to identify, one, which of the vine multiplication models in use is the most financially viable; and two, determine the number of vine multipliers needed to adequately supply clean sweetpotato vine in the two countries. Results show that at vine multiplier level, it is more financially feasible to multiply vines without using protected structures that guard against virus infection. Rapid multiplication is also more profitable than conventional vine multiplication. Generally, multiplication of vines in the low virus pressure areas is more profitable than in the high virus pressure areas. To supply enough quality vines to root producers in the two countries, 115 vine multipliers need to be established in Uganda and 184 vine multipliers in Tanzania, each with at least 0.4 ha under rapid vine multiplication.