Sweetpotato (SP) (Ipomoea batatas (L) Lam) is a dicotyledonous perennial root tuber plant belonging to Convolvulaceae family. Ipomoea is one genus among 55 Convolvulaceae genera. Most of it’s 500 species are ploidy ranging 2x to 6x with SP possessing both 4x and 6x. SP has economic significance with global production ranging above 133Mt. SP is ranked 7^th most important crop worldwide and 5^th in Africa. A major challenge to SP production is weevil and virus infestation. This article describes various viruses affecting SP as they cause most biotic production constraints. About 20 different viruses have been characterised and grouped as asymptomatic and or symptomatic. Among these viral families some threaten SP cultivar decline such as Potyviridae, Geminiviridae and Sweetpotato chlorotic stunt virus (SPCSV). With single infection most viruses are symptomless. However, synergism exits between most interactions (Virus-host interaction) inducing symptoms. The most common viral disease widely spread in Africa and Peru is the sweetpotato virus disease (SPVD) mostly caused by simultaneous Sweetpotato feathery mottle virus (SPFMV) and sweetpotato chlorotic stunted virus (SPCSV) attacks.