Catholic Relief services (CRS) was established in 1960 in Rwanda. A key objective was to introduce and support various initiatives aimed at improving food security and nutrition and reducing poverty among vulnerable rural poor. This presentation documents CRS integrated approach combining interventions related to agriculture, nutrition, hygiene and sanitation, and economic strengthening that enable vulnerable people to have sustainable food security while increasing their resiliency to different shocks, including effects of HIV/AIDS, chronic malnutrition, poverty and other social challenges. One such example is the promotion of Orange fleshed sweetpotato (OFSP) which has shown a positive effect on the living conditions of vulnerable populations in enhancing access to highly nutritious food and to the improvement of nutrition status. Some beneficiaries have been able to increase household income from OFSP-processed products. This article concludes by recommending other stakeholders involved in the promotion of OFSP to use the same integrated approach and involve the beneficiaries in the full value chain of the OFSP.